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DEPAKOTE may possibly impact how other medicines work, together with other medicines might have an impact on how DEPAKOTE operates. Employing DEPAKOTE with other medicines could potentially cause severe Unintended effects. Do not commence or end other medicines with no conversing with your healthcare supplier.
Plasma clearance and quantity of distribution without spending a dime diazepam have been minimized by 25% and twenty%, respectively, in the existence of valproate. The elimination half-life of diazepam remained unchanged upon addition of valproate.
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two. Depakote could damage your unborn baby. If you take Depakote through pregnancy for virtually any health-related affliction, your baby is at risk for significant start defects that affect the brain and spinal cord (including spina bifida or neural tube defects). These defects can start off in the main month, even before you know you happen to be Expecting.
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Due to the fact people ended up also taken care of with other antiepilepsy medication, it really is impossible, in most cases, to ascertain whether or not the subsequent adverse reactions is often ascribed to Depakote alone, or The mix of Depakote along with other antiepilepsy medications.
As a result of hazard towards the fetus of lowered IQ, neurodevelopmental Conditions, neural tube defects, along with other key congenital malformations, which can come about pretty early in pregnancy, valproate should not be utilized to treat Ladies with epilepsy or bipolar condition who're pregnant or who strategy to become pregnant unless other medications have unsuccessful to deliver adequate symptom control or are if not unacceptable.
Primidone, that's metabolized to your barbiturate, may be involved in a similar interaction with here valproate.
Significant heart indications for example quick, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; and unexpected dizziness, lightheartedness, or passing out;
There have already been various experiences of acute or subacute cognitive decline and behavioral adjustments (apathy or irritability) with cerebral pseudoatrophy on imaging connected to valproate therapy; both the cognitive/behavioral modifications and cerebral pseudoatrophy reversed partially or completely soon after valproate discontinuation.
drowsiness or sleepiness in the elderly. This Serious drowsiness may result in you to definitely eat or consume lower than you Commonly would. Convey to your healthcare supplier if You aren't ready to eat or drink while you Commonly do. Your Health care provider might start off you in a lessen dose of Depakote.
Suicidal Considering and Behavior Counsel patients, their caregivers, and families that AEDs, including Depakote, may increase the chance of suicidal ideas and behavior also to be inform for that emergence or worsening of symptoms of melancholy, any unconventional modifications in mood or habits, or the emergence of suicidal ideas, habits, or views about self-hurt.